Targeted renal therapies through microbubbles and ultrasound☆
نویسندگان
چکیده
منابع مشابه
Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin.
BACKGROUND Routine methods capable of assessing tissue inflammation noninvasively are currently not available. We hypothesized that tissue retention of microbubbles targeted to the endothelial cell adhesion molecule P-selectin would provide a means to assess inflammation with ultrasound imaging. METHODS AND RESULTS Phospholipid microbubbles targeted to P-selectin (MB(p)) were created by conju...
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The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor tissue under the action of tumor-directed therapeutic ultrasound. Tumor accumulation of nanoemulsions was confirmed by ultrasound imaging. Dramatic regression of ovarian, breast, and orthotopic pancreatic tumors was o...
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Conventional ultrasound has well known short comings in the detection and characterisation of focal liver lesions. A false negative rate of up to 30% has been quoted in the detection of liver metastases and its accuracy in the characterisation of focal liver lesions is poor compared to computed tomography (CT) and magnetic resonance (MR). Ultrasound microbubble contrast agents have redressed th...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2010
ISSN: 0169-409X
DOI: 10.1016/j.addr.2010.10.002